BRITISH SOCIETY FOR HAEMATOLOGY

Why is this study important?

• Intra-cranial haemorrhage is one of the most serious side-effects of severe thrombocytopenia in haematology patients.
• Intra-cranial haemorrhage is rare, but has devastating consequences. Death or major morbidity in the majority of cases.
• It is unknown why some patients bleed and others don’t.
• The risk of significant bleeding is poorly correlated with the platelet count.

Aims of the study

• To identify risk factors for serious haemorrhage.
• Use information from this study to guide the management of patients in the future.
• Decrease a patient’s exposure to prophylactic platelet transfusions if they have a low risk of bleeding.
• Develop intensified management strategies for patients with a high risk of bleeding. These could include higher platelet transfusion thresholds, maintaining higher haematocrits, maintaining higher fibrinogen levels or use of other agents such as tranexamic acid.

Further information

Please contact:      

HASS Coordinator:            Lise.Estcourt@nhsbt.nhs.uk

Website:                               http://hospital.blood.co.uk/research/index.asp

InCiTe Study protocol